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                  Helping you help patients.

                  Understand your patient’s condition with greater precision.

                  SmartGut? uses precision sequencing? technology to accurately identify dozens of important species and genera.

                  SmartGut helps you gain insight into your patients’ gut health. Patients self-sample conveniently at home, then mail samples to the lab. Once testing is complete, we will email you and your patient a?HIPAA-compliant link?to a PDF. This detailed report shows dozens of microorganisms as well as information on how they relate to gut health.


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                  Join The Microbiome Innovation Challenge and tell us about your ideas.

                  SmartGut Resources

                  Learn more about our company, our SmartGut? test, the groundbreaking science at uBiome, and how our work is advancing the field of microbial genomics.

                  To start ordering our clinical tests, create a provider account now. If you have any questions, contact our Clinical Partnerships Team.


                  SmartGut metrics and methods

                  The uBiome SmartGut screening test includes information on dozens of clinically relevant bacteria and other microorganisms associated with health and disease.

                  • 1Safe at ambient temperatures

                    SmartGut collection kits include a stabilization buffer, which effectively lyses and kills all microorganisms and preserves the sample DNA for transport at ambient temperatures to our CLIA-certified and CAP-accredited laboratory.

                  • 2Precision Sequencing? technology

                    We use patent pending Precision Sequencing? technology to extract DNA from microorganisms present in a SmartGut sample, allowing us to achieve greater precision in identifying specific test targets. All targeted genes are sequenced using Illumina? Next-Generation sequencing.

                  • 3Secure computing cluster

                    We run our analysis on a secure, high-performance computing cluster. Once we’ve determined a sample’s taxonomic composition, we compare it to an established healthy reference range that is based on the world’s largest microbiome dataset.

                  • 4Taxonomic annotation

                    Our bioinformatics pipeline enables us to generate a taxonomic annotation of the dozens of clinically relevant species and genera that may be present in a SmartGut sample. Analysis of SmartGut samples is performed using high-throughput bioinformatics, incorporating phylogenetic algorithms and custom databases specifically developed for microbiome data.

                  • 5Extensive literature review

                    Our extensive and ongoing review of scientific literature has identified numerous associations between the microorganisms on the SmartGut panel and human health and disease. The SmartGut test report incorporates this information and provides insights into how specific microorganisms may affect your patients.

                  • 6High specificity and sensitivity

                    On average, the sensitivity, specificity, precision, and negative prediction value for the microorganisms on our target list are 99.0%, 100%, 98.9%, and 100%, for the species, and 97.4%, 100%, 98.5%, and 100% for the genera, respectively. Using advanced DNA sequencing technology, we can achieve much better test metrics than other similar tests.

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                  The uBiome SmartGut microbiome test can help in understanding the following conditions:

                  • Irritable bowel syndrome
                  • Inflammatory Bowel Disease including Crohn’s Disease and Ulcerative Colitis
                  • Constipation or diarrhea
                  • Abdominal tenderness
                  • Bloating
                  • Flatulence
                  • Obesity
                  • Diabetes
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                  World-class science

                  With over 50 scientists on our team from universities like UCSF, Stanford, Harvard, UCSD, Cambridge (UK) and Oxford (UK), over 300 scientific papers, and over 100 patents filed (73 published, 6 granted) on our technology, uBiome continues to break new ground scientifically.

                  Learn more about our science

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                  CLIA-licensed and CAP-accredited laboratory in San Francisco

                  Your samples are in safe hands with us. Only around 3% of laboratories in the US have the level of accreditation achieved by the uBiome lab, which has been accredited by the College of American Pathologists (CAP) and has received a Clinical Laboratory Improvement Amendments (CLIA) certificate.

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                  Protecting your privacy

                  Your privacy is our top priority. To ensure the confidentiality of your data and your results, we use multiple layers of encryption and the highest levels of computer security. You control your data, and can choose whether or not you consent to having your data anonymized and aggregated into uBiome research studies.

                  uBiome’s social mission

                  uBiome’s mission is to advance the science of the microbiome and make it useful to people. Through our research with thousands of citizen scientists and dozens of universities, including Harvard, Stanford, UCSF and others, we have gathered millions of data points and built a set of tools that have enabled us to create clinical tests for healthcare providers and patients.

                  For people

                  We are committed to empowering people to understand and take greater control of their health. Through our uBiome Explorer kits and our microbiome database – the largest in the world – we give people access to tools to better understand the microbiome.

                  For science

                  To advance the science of the microbiome, we work with over 1,000 researchers from around the world at institutions such as Harvard, Stanford, UCSF, University College London, and the National University of Singapore.

                  For the world

                  We also work with over 150,000 citizen scientists in more than 80 countries. Our projects include large-scale citizen scientist studies, partnerships with researchers and organizations, and support for underfunded scientific discovery via our $1 million Microbiome Impact Grant Initiative (as part of the White House National Microbiome Initiative).